Journal of Liver Cancer

Jin Kim

5 Articles

A Case of Paraplegia after Successful Treatment of Cyberknife for Hepatocellular Carcinoma: Geum Youb Noh, Chul Ju Han, Youn Joo Kim, Ki Young Yang, Su Cheol Park, Jin Kim, Yu Cheol Kim, Mi Sook Kim; Journal of the Korean Liver Cancer Study Group. 2011;11(2):165-171. Published online September 30, 2011

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Abstract PDF: Radiation therapy (RT) is one of the managements for unresectable hepatocellular carcinoma (HCC). Traditionally, RT has played only a limited role in HCC treatment because of its low efficacy and the low tolerance of the liver for this modality. However, as the technology of RT grows rapidly in recent years, indication of RT for HCC has been extended remarkably. Stereotactic body radiation therapy (SBRT) is a technique that allows precise delivery of a large ablative radiation dose to the tumor while sparing normal surrounding tissue in 1 to 5 fractions. As RT becomes useful therapeutic strategy, the important problem is that there could be serious complication after RT. Here we present a case of 54 years old male with advanced stage of HCC, who underwent a serious neurologic complication of paraplegia following Cyberknife (CK) treatment. He had a huge HCC in right lobe of the liver, and initially transarterial chemoembolization (TACE) was performed with an unsatisfactory response. Therefore, CK was performed, and another TACE was done for a new lesion, which was followed by remarkable complete remission of the tumor. However, paraplegia developed in both of his lower extremities a year after CK. Investigation has shown radiation myelitis as the cause of paralysis. Three and a half years have passed since CK treatment, and HCC is still in complete remission state, however, paraplegia is persistent now. Radiation myelitis should be considered as a complication, when CK is applied to treatment of HCC.

A Case of Hepatocellular Carcinoma Who had Surgical Resection Following TACE and Sorafenib Chemotherapy: Geum Youb Noh, Chul Ju Han, Youn Joo Kim, Ki Young Yang, Su Cheol Park, Jin Kim, Yu Cheol Kim, Yoon Hee Choi, Hyo Rak Lee; Journal of the Korean Liver Cancer Study Group. 2011;11(1):65-68. Published online February 28, 2011

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Abstract PDF: Surgical resection for hepatocellular carcinoma (HCC) is one of the managements, showing improved long term survival. Nowadays, it is being accepted as the main curative treatment. However, the biggest problem we used to face is that surgery cannot be applied at the point of presentation in many patients due to advanced stage. Here we present a case of 54 years old female, who had transarterial chemoembolization (TACE) and sorafenib due to advanced stage of HCC, and later underwent curative surgery due to remarkable response. She had a CT scan of abdomen, which showed multiple huge masses. HCC was confirmed by ultrasonography-guided liver biopsy. TACE was performed once. After TACE, the size of masses increased. Therefore, sorafenib was administered and then continued for 9 months. As partial response was obtained at that time, surgical resection was successfully done. In the pathological report of removed tumor, we could confirm total necrosis of tumor. Now, its been 6 months and she is followed up without any recurrence.

Two Cases of Hepatocellular Carcinoma with Extrahepatic Metastasis Who Showed Complete Remission Following Doxorubicin and Cisplatin (AP) Combination Chemotherapy in Reduced Dosage: Seung Bum Nam, Chul Ju Han, Ho Jin Lee, Youn Joo Kim, Ki Young Yang, Su Cheol Park, Jin Kim, Yu Cheol Kim; Journal of the Korean Liver Cancer Study Group. 2010;10(1):55-60. Published online June 30, 2010

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Abstract PDF: The effect of systemic chemotherapy in patients with advanced HCC is very limited, not only in regard to poor response to cytotoxic chemotherapeutic agents but also poor tolerance to therapy and related adverse effects. Herein, we report two
case
s of hepatocellular carcinoma (HCC) with extrahepatic metastasis who achieved complete remission following administration of doxorubicin and cisplatin in reduced dosage. The first case was a 41-year-old male who had HCC with multiple lung and intraabdominal lymph nodes metastasis. After 9 cycles of chemotherapy with 50% reduced dosage, he achieved a complete remission of both primary and metastatic lesions. He showed no evidence of disease for 11 more months during follow-up and still lives without recurrence. The second case was a 61-year-old female who had HCC with inferior vena cava thrombosis and multiple lung metastasis. After one cycle of treatment with 25% reduced dosage, she underwent life-threatening toxicities and poor tolerance to chemotherapy and further treatment was discontinued. However, she achieved a complete remission of both primary and metastatic lesions. Following 26 months of recurrence free period, she suffered from a recurrent tumor near previously treated lesion, which was successfully treated by TACE and radiation therapy. This modified doxorubicin and cisplatin regimen in reduced dosage could be used as means of evading life threatening toxicity and selecting out responders to systemic chemotherapy with reduced risk.

A Case of Surgically Diagnosed, Small Hepatocellular Carcinoma with Well-differentiated Type: seung-Seok Ki, Duck-Ryung Kim, Sook-Hyang Jeong, Chul-Ju Han, Jin Kim, Yu-Cheol Kim, Jin-Oh Lee, Sang-Beom Kim, Dong-Wook Choi, Young Han Kim, Dong-Hee Park, Byung-Hee Lee, Sun-Hoo Park; Journal of the Korean Liver Cancer Study Group. 2004;4(1):39-41. Published online June 30, 2004

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Abstract PDF: The diagnosis of small hepatocellular carcinoma(HCC) of well-differentiated type is not always easy and is often problematic in clinical practice. Hepatic resection provides excellent survival for well-differentiated HCC. We report a case of small HCC with well-differentiated type, which was surgically diagnosed, in a 47-year-old man.

A Case of Early, Widespread Intrahepatic Recurrence of Hepatocellular Carcinoma after Surgical Resection: Seung-Seok Ki, Duck-Ryung Kim, Sook-Hyang Jeong, Chul-Ju Han, Jin Kim, Yu-Cheol Kim, Jin-Oh Lee, Sang-Beom Kim, Dong-Wook Choi, Young Han Kim, Dong-Hee Park, Byung-Hee Lee, Sun-Hoo Park; Journal of the Korean Liver Cancer Study Group. 2004;4(1):59-61. Published online June 30, 2004

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Abstract PDF: Liver resection is the major curative treatment modality for hepatocellular carcinoma(HCC). However, postoperative intrahepatic recurrence is common and remains the main obstacle to long-term cure. Although small HCC without vascular invasion showed more than 50 % of 5-year survival rate, some patients with HCC at early stage cannot attain long-term survival after hepatectomy. We report here a case of stage Ⅰ HCC in a 64-year-old man showing early, widespread intrahepatic metastasis at 4 months after resection.